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Salvia divinorum (also known as Diviner's sage, María Pastora or simply Salvia, although the genus name is shared among many plants) is a psychoactive plant, a member of the sage genus and the Lamiaceae (mint) family. The plant is grown by the Mazatec indigenous people of the Oaxaca mountains of southern Mexico in isolated, moist, and secret plots. It has been used as an entheogen by their shamans for centuries for healing during spirit journeys. It is thought to be a cultigen. No definitively wild populations have been found. The Latin name Salvia divinorum literally translates to "sage of the diviners".

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Unless you believe that Salvia divinorum is the old Mexica (Aztec) narcotic plant pipiltzintzintli (I don’t), the story of this fascinating mint began in the late 1930s. When R. Gordon Wasson and Albert Hoffman brought back material for Carl Epling to identify (Wasson 1962, 1963; Epling and Játiva-M 1962), they ended a search that had lasted nearly a quarter of Officinalis a century. Their party traveled through Oaxaca under the auspices of a famous Mexican anthropologist, Roberto

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Weitlaner (an Austrian by birth), who had been guiding expeditions to Oaxaca for decades (Pompa y Pompa 1966). I’ve quoted everything relative to S. divinorum from each of the following rather rare references, translating to English where necessary.

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Divinorium Carl Epling, who first described S. divinorum,

reported the newer as having a blue buy Salvia divinorum Hofmann corolla, and it has been illustrated this way in the literature (Epling and Jativa-M, 1962; Schultes, 1976). However, this description has been shown to be an error, as all living specimens of the plant have had blossoms with white corollas Smoking Salvia Farinacea and purple calyces (Diaz, 1975a; Emboden, 1979).

The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action. R. Gordon Wasson, the famed ethnobotanist who introduced psilocybe mushrooms to western society, was also the first to personally describe an experience with Sage Goddess Emerald Essence Salvia divinorum. In July of 1961 he participated in a healing ceremony performed by a Mazatecan curandera. Wasson ingested the squeezed juice of 34 pairs of leaves, and described the results as "coming on sooner (than the mushrooms), being less sweeping, and lasting a shorter time. It did not go beyond the initial effects of the mushrooms - dancing colors in elaborate, three- dimensional designs." In Salvia Extraction 1962 Wasson was joined in Oaxaca by Swiss pharmacologist Albert Hofmann, inventor of LSD, who also first isolated psilocybin from mushrooms gathered in this same region. Hofmann brought an alcohol extract of Salvia divinorum back to Switzerland where he attempted to isolate the active component. He was unsuccessful, finding the extract to no longer be active, and suggested that the plant's active principal was unstable.
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Amongst the Mazatecs, Salvia divinorum (Diviner's sage) is known under such names as ska Maria Pastora and Hierba Maria, which translate as "the herb of Mary" or "leaves of Mary the Shepherdess". In a recent paper, Jonathan 0tt has noted that the Mazatecs lack an indigenous name for Salvia divinorum, both the Christian theme of Mary, Herb as well as sheep, having been introduced to the region during the Spanish conquest. The Mazatecs also list a method of consuming this plant that does not efficiently utilize its psychoactive content, and seem to be generally unaware of its tremendous potency. Based on this information, and the likelihood of its being a cultigen, Ott has suggested that Salvia divinorum may be a post-conquest introduction to the Sierra Mazateca. However, it has also been suggested, initially by R. Gordon Wasson, that Salvia divinorum may be the Aztec plant Pipiltzintzintli, an entheogen that was briefly described by a 17th century Spanish friar. Ott has found that the little information available regarding Pipiltzintzintli supports this hypothesis, while ruling out several other plants that have been Hyssopus New Highs Hyssopus suggested as candidates for this Aztec sacrament.

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