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Salvia divinorum is a very rare plant, being found in only a few ravine locations in the Palatable Sierra Mazateca mountains. The plant is easily propagated by cuttings, and during the past few decades it has made its way into numerous botanical gardens and private collections around the world. Virtually all of the Salvia divinorum in circulation has been vegetatively propagated from two parent clones of this species. The first specimen was collected by R. Gordon Wasson in 1962. A second, so called "palatable" strain was collected by Bret Blosser in Palatable 1991. The "palatable" variety is actually still quite salvia divinorum seeds bitter, although less so than the Wasson clone.

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Salvia divinorum (also known as Diviner's sage, María Pastora or simply Salvia, although the genus name is shared among Salvia Divinorum Extract many plants) is a psychoactive plant, a member of the sage genus and the Lamiaceae (mint) family. The plant is grown by the Mazatec indigenous people of the Oaxaca mountains of southern Mexico in isolated, moist, and secret plots. It has been used as an entheogen by their shamans for centuries for healing during spirit journeys. It is thought to be a cultigen. No definitively wild populations have been found. The Latin name Salvia divinorum literally translates to "sage of the diviners".

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'Buzzy' is what came to mind when we first smoked this one The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.

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