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Salvia divinorum is a very rare plant, being found in only a few ravine locations in the Sierra Mazateca mountains. The plant is easily propagated by cuttings, and during the past few decades it has made its way into numerous botanical gardens and private collections around the world. Virtually all of the Salvia divinorum in circulation has been vegetatively propagated from two parent clones of this species. The first specimen was collected by R. Gordon Salvia Splendens Wasson in 1962.
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It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists.
This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism.
Salvinorin A is unique in Hyssopus Officinalis that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist.
It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism.
Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg [1. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists.
This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.The primary Officinalis psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known.
It is active at doses as low as 100 µg 1. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.
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We deliver FAST Australia Wide using Express Post and offer FREE SHIPPING on all orders over $100 R. Gordon Wasson, the famed ethnobotanist who introduced psilocybe mushrooms to western society, was also the first to personally describe an experience with Salvia divinorum. In July of 1961 he participated in a healing ceremony performed by a Mazatecan curandera. Wasson ingested the squeezed juice of 34 pairs of leaves, and described the results as "coming on sooner (than the mushrooms), being less sweeping, and lasting a shorter time. It did not go beyond the initial effects of the mushrooms - dancing colors in elaborate, three- dimensional designs." In 1962 Wasson was joined in Oaxaca by Swiss pharmacologist Albert Hofmann, inventor of LSD, who also first isolated psilocybin from mushrooms gathered in this same region. Hofmann brought an alcohol extract of Salvia divinorum back to Switzerland where he attempted to isolate the active component. He was unsuccessful, finding the extract to no longer be active, and suggested that the plant's active principal was unstable.
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smoking Salvia guaranitica overall Amongst the Mazatecs, Salvia divinorum (Diviner's sage) is known under such names as ska Maria Pastora and Hierba Maria, which translate as "the herb of Mary" or "leaves of Mary the Shepherdess". In a recent paper, Jonathan 0tt has noted that the Mazatecs lack an indigenous name for Salvia divinorum, both the Christian theme of Mary, as well as sheep, having been introduced to the region during the Spanish conquest. The Mazatecs also list a method of consuming this plant that does not efficiently utilize its psychoactive content, and seem to be generally unaware of its tremendous potency. Based on this information, and the likelihood of its being a cultigen, Ott has suggested that Salvia divinorum may be a post-conquest introduction to the Sierra Mazateca.
However, it has also been suggested, initially by R. Gordon Wasson, that Salvia divinorum may be the Aztec plant Pipiltzintzintli, an entheogen that was briefly described by a 17th century Spanish Buy Salvia friar. Ott has found that the little information available regarding Pipiltzintzintli supports this hypothesis, while ruling out several other plants that have been suggested as candidates for this Aztec sacrament. Salvia divinorum (also known as Diviner's sage, María Pastora or simply Salvia, although the genus name is shared among many plants) is a psychoactive plant, a member of the sage genus and the Lamiaceae (mint) family. The plant is grown by the Mazatec indigenous people of the Oaxaca mountains of southern Mexico in isolated, moist, and secret plots. It has been used as an entheogen by their shamans for centuries for healing during spirit journeys. It is thought to be a cultigen. No definitively wild populations have been found. The Latin name Salvia divinorum literally translates to "sage of the diviners". 95
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TRIBE 3 Carl Epling, who first described S. divinorum, reported the newer as having a blue corolla, and it has been illustrated this way in the literature (Epling and Jativa-M, 1962; Schultes, 1976). However, this description has been shown to be an error, as all living specimens of the plant have had blossoms with white corollas and purple calyces (Diaz, 1975a; Emboden, 1979). Diterpen
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A discussion of the role of ska Maria Pastora in the native pharmacopeia is based on previous reports and fieldwork by the authors, with a Mazatec shaman. A discussion of the role of ska Maria Pastora in the native pharmacopeia is based on previous reports and fieldwork by the authors, with a Mazatec shaman. R. Gordon Wasson, the famed ethnobotanist who introduced psilocybe mushrooms to western society, was also the first to personally describe an experience with Salvia divinorum. In July of 1961 he participated in a healing ceremony performed by a Mazatecan curandera. Wasson ingested the squeezed juice of 34 pairs of leaves, and described the results as "coming on sooner (than the mushrooms), being less sweeping, and lasting a shorter time. It did not go beyond the initial effects of the mushrooms - dancing colors in elaborate, three- dimensional designs." In 1962 Wasson was joined in Oaxaca by Swiss pharmacologist Albert Hofmann, inventor of LSD, who also first isolated psilocybin from mushrooms gathered in this same region. Hofmann brought an alcohol extract of Salvia divinorum back to Switzerland where he attempted to isolate the active component. He was unsuccessful, finding the extract to no longer be active, and suggested that the plant's active principal was unstable. Packed in 6 capsule doses
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