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TRIBE 3 Salvia divinorum (also known as Diviner's sage, María Pastora or simply Salvia, although the genus name is shared among many plants) is a psychoactive plant, a member of the sage genus and the Lamiaceae (mint) family. The plant is grown by the Mazatec indigenous people of the Oaxaca mountains of southern Mexico in isolated, moist, and secret plots. It has been used as an entheogen by their shamans for centuries for healing during spirit journeys. It is thought to be a cultigen. No definitively wild populations have been found. The Latin name Salvia divinorum literally translates to "sage of the diviners". 99
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Available in The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin
salvia tea A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins
salvia divornum A-E, Salvia Splendens salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism.
Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg [1. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can
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TRIBE 3 A discussion of the role of ska Maria Pastora in the native pharmacopeia is based on Diviner S previous Diviner S reports and fieldwork by the authors, with a Mazatec shaman. Salvia divinorum is a very rare plant, being found in only a few ravine locations in the Sierra Mazateca mountains. The plant is easily propagated by cuttings, and during the past few decades it has made its way into numerous botanical gardens and private collections around the world. Virtually all of the Salvia divinorum in circulation has been vegetatively propagated from two parent clones of this species. The first specimen was collected by R. Gordon Wasson in 1962. A second, so called "palatable" strain was collected by Bret Blosser in 1991. The "palatable" variety is actually still quite bitter, although less so than the Wasson clone. There are a few other strains being maintained, some of which were grown from seed, but these are not in general circulation. So does one's overall
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