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R. Gordon Wasson, the famed ethnobotanist who introduced psilocybe mushrooms to western society, was also the first to personally describe an experience with Salvia divinorum. In July of 1961 he participated in a healing ceremony performed by a Mazatecan curandera. Wasson ingested the squeezed juice of 34 pairs of leaves, and described the results as "coming on sooner (than the mushrooms), being less Enzo Salvi sweeping, and lasting a shorter time. It did not go beyond the initial effects of the mushrooms - dancing colors in elaborate, three- dimensional designs." In 1962 Wasson was joined in Oaxaca by Swiss pharmacologist Albert Hofmann, inventor of LSD, who also first isolated psilocybin from mushrooms gathered in this same region. Hofmann brought an alcohol extract of Salvia divinorum back to Switzerland where he attempted to isolate the active component. He was unsuccessful, finding the extract to no longer be active, and suggested that the plant's active principal was unstable. Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant produces are compared to those of the other hallucinogens employed by the Mazatecs, the morning glory, Rivea corymbosa L., Hallier f. and the psilocybin-containing mushrooms. Divorium
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Amongst the Mazatecs, Salvia divinorum (Diviner's sage) is known under such names as ska Maria Pastora and Hierba Maria, which translate as "the herb of Mary" or "leaves of Mary the Shepherdess". In a recent paper, Jonathan 0tt has noted that the Mazatecs lack an indigenous name for Salvia divinorum, both the Christian theme of Mary, as well as sheep, having been introduced to the region during the Spanish conquest. The Mazatecs also list a method of consuming this plant that does not efficiently utilize its psychoactive content, and seem to be generally unaware of its tremendous potency. Based on this information, and the likelihood of its being a cultigen, Ott has suggested that Salvia divinorum may be a post-conquest introduction to the Sierra Mazateca. However, it has also been suggested, initially by R. Gordon Wasson, that Salvia divinorum may be the Aztec plant Pipiltzintzintli, an entheogen that was briefly described by a 17th century Spanish friar. Ott has found that the little information available regarding Pipiltzintzintli supports this hypothesis, while ruling out several other plants that have been suggested as candidates for this Aztec sacrament. 00
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The law: Not controlled under the Misuse of Drugs Act The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action. Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant produces are compared to those of the other hallucinogens employed by the Mazatecs, the morning glory, Rivea corymbosa L., Hallier f. and the psilocybin-containing mushrooms. 99
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