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Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Andorra Salvia Mexico. The psychotropic effects the plant produces are compared to those of the other hallucinogens employed by the Mazatecs, La Salvia the morning glory, Rivea corymbosa L., Hallier f. and the psilocybin-containing mushrooms.

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The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1]. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist. It has been demonstrated that the effects of salvinorin A are blocked by kappa opioid receptor antagonists. This indicates that the effects of S. divinorum can be largely, if not entirely, attributed to kappa agonism. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state via this mechanism of action.The primary psychoactive constituent is trans-neoclerodane diterpenoid known as salvinorin A. Salvia also contains Salvia Splendens the closely related compounds salvinorins B-G, divinatorins A-E, salvinicins A and B, and hardwickiic acid. Salvinorin A is the most potent naturally-occurring hallucinogen known. It is active at doses as low as 100 µg 1. Recent research has shown that salvinorin A is a remarkably potent and selective kappa opioid receptor agonist.
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